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タイトル :FGF-2 suppresses cellular senescence of human mesenchymal stem cells by down-regulation of TGF-β2
著者 :Ito, Tomomi
Sawada, Rumi
Fujiwara, Yoko
Seyama, Yousuke
Tsuchiya, Toshie
別言語の著者 :藤原, 葉子
発行日 :2007-5-21
抄録 :Human mesenchymal stem cells (hMSCs) are able to both self-replicate and differentiate into a variety of cell types. Fibroblast growth factor-2 (FGF-2) stimulates the growth of hMSCs in vitro, but its mechanisms have not been clarified yet. In this study, we investigated whether cellular senescence was involved in the stimulation of hMSCs growth by FGF-2 and the expression levels of transforming growth factor-β1 and -β2 (TGF-βs). Because hMSCs were induced cellular senescence due to long-term culture, FGF-2 decreased the percentage of senescent cells and suppressed G1 cell growth arrest through the suppression of p21(Cip1), p53, and p16(INK4a) mRNA expression levels. Furthermore, the levels of TGF-βs mRNA expression in hMSCs were increased by long-term culture, but FGF-2 suppressed the increase of TGF-β2 mRNA expression due to long-term culture. These results suggest that FGF-2 suppresses the hMSCs cellular senescence dependent on the length of culture through down-regulation of TGF-β2 expression.
資料種別 :学術雑誌論文
URI :http://hdl.handle.net/10083/1127
NII書誌ID :AA00564395
AA11542044
公開者・出版者 :Academic Press
DOI :10.1016/j.bbrc.2007.05.067
PMID :17532297
権利 :Copyright © 2007 Elsevier Inc. All rights reserved.
掲載雑誌 :Biochemical and biophysical research communications Vol.359 no.1 p.108 -114
出現コレクション:4 自然科学