{"created":"2021-03-01T06:40:00.301113+00:00","id":34694,"links":{},"metadata":{"_buckets":{"deposit":"07dcbfa7-8fd5-449b-98a8-72ce9b1fdfb0"},"_deposit":{"id":"34694","owners":[],"pid":{"revision_id":0,"type":"depid","value":"34694"},"status":"published"},"_oai":{"id":"oai:teapot.lib.ocha.ac.jp:00034694","sets":["347:359:668"]},"item_11_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-08-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"12","bibliographicPageStart":"7","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"お茶の水女子大學自然科學報告"}]}]},"item_11_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_11_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"紀要論文","subitem_description_type":"Other"}]},"item_11_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Telomerase is known as a ribonucleoprotein enzyme essential for the repair of replication-induced deletion of chromosome terminal in most eukaryotes. Although the regulatory mechanism of telomerase inactivation and re-activation has not yet been clarified, there is a possibility that telomerase activity is regulated by phosphorylation and dephosphorylation. DNA-dependent protein kinase (DNA-PK) is considered to be a critical enzyme in DNA double-strand break repair and possibility of involvement of this enzyme in the regulation of telomerase is expected. To examin correlation between telomerase and DNA-PK, we purified DNA-PK from human leukaemic MOLT-4 cells by successive column chromatography. Through the conventional process of purification, DNA-PK activity was accompanied by telomerase activity. We used modified purification protcol in this study, and tinaly, succeeded in purification of DNA-PK separately from telomerase activity. This DNA-PK didn't show any effect on the telomerase activity, and these results indicate that the telomerase may not be regulated via phosphorylation with DNA-PK.","subitem_description_type":"Other"}]},"item_11_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"70637","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イケダ, フミ"}]},{"nameIdentifiers":[{"nameIdentifier":"70638","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マツモト, ヨシヒサ"}]},{"nameIdentifiers":[{"nameIdentifier":"70639","nameIdentifierScheme":"WEKO"}],"names":[{"name":"スズキ, ノリオ"}]},{"nameIdentifiers":[{"nameIdentifier":"70640","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ムラカミ-ムロフシ, キミコ"}]}]},"item_11_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"お茶の水女子大学"}]},"item_11_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00033958","subitem_source_identifier_type":"NCID"}]},"item_11_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00298190","subitem_source_identifier_type":"ISSN"}]},"item_11_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"400","subitem_subject_scheme":"NDC"}]},"item_11_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"1151019 bytes"}]},"item_11_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"紀要論文"}]},"item_11_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Departmental Bulletin Paper"}]},"item_11_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_11_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"03"}]},"item_11_text_79":{"attribute_name":"所属","attribute_value_mlt":[{"subitem_text_value":"Department of Biology, Faculty of Sience, Ochanomizu University"},{"subitem_text_value":"Department of Radiation Oncology, Faculty of Medicine, University of Tokyo"},{"subitem_text_value":"Department of Radiation Oncology, Faculty of Medicine, University of Tokyo"},{"subitem_text_value":"Department of Biology, Faculty of Sience, Ochanomizu University"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ikeda, Fumi"}],"nameIdentifiers":[{"nameIdentifier":"70633","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Yoshihisa"}],"nameIdentifiers":[{"nameIdentifier":"70634","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Norio"}],"nameIdentifiers":[{"nameIdentifier":"70635","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murakami-Murofushi, Kimiko"}],"nameIdentifiers":[{"nameIdentifier":"70636","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-19"}],"displaytype":"detail","filename":"KJ00004470889.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004470889.pdf","url":"https://teapot.lib.ocha.ac.jp/record/34694/files/KJ00004470889.pdf"},"version_id":"1cd36309-4516-4ca3-b855-942f45eeacb8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Examination of The Correlation between DNA-dependent Protein Kinase and Telomerase Activity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Examination of The Correlation between DNA-dependent Protein Kinase and Telomerase Activity"}]},"item_type_id":"11","owner":"1","path":["668"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-04-23"},"publish_date":"2007-04-23","publish_status":"0","recid":"34694","relation_version_is_last":true,"title":["Examination of The Correlation between DNA-dependent Protein Kinase and Telomerase Activity"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-12T05:39:10.267989+00:00"}