@article{oai:teapot.lib.ocha.ac.jp:00034703,
 author = {Shimada, Yukiko and Nakano, Mariko and Murakami-Murofushi, Kimiko},
 issue = {2},
 journal = {お茶の水女子大學自然科學報告},
 month = {Dec},
 note = {application/pdf, 紀要論文, Telomere length and telomerase activity were determined in peripheral blood leukocytes isolated from normal donors and human, immortal leukemic cell lines derived from different cell sources. Telomeres in normal leukocytes had shorten with age of donors but no telomerase activity was detected in these cells. An apparent shortening of telomeres was observed in most of immortal cells, and they showed telomerase activity with a high processivity. The expression of telomerase may be required as a critical step for tumorgenesis, but telomere length may not be a determinants of malignancy of cancer cells. The enzyme activitywas sensitive to pretreatment with RNase A and proteinase K, suggesting the nature of this enzyme as a ribonucleoprotein.},
 pages = {35--43},
 title = {TELOMERE AND TELOMERASE IN HUMAN LEUKOCYTES AND IMMORTAL CELL LINES},
 volume = {47},
 year = {1996}
}