{"created":"2021-03-01T06:06:43.130476+00:00","id":4893,"links":{},"metadata":{"_buckets":{"deposit":"640b917a-90f8-46ff-bf13-130eeed0ad4c"},"_deposit":{"id":"4893","owners":[],"pid":{"revision_id":0,"type":"depid","value":"4893"},"status":"published"},"_oai":{"id":"oai:teapot.lib.ocha.ac.jp:00004893","sets":["226:216:221"]},"item_12_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-12-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"284","bibliographicPageStart":"275","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Journal of toxicological sciences"}]}]},"item_12_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"学術雑誌論文","subitem_description_type":"Other"}]},"item_12_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Peroxisome proliferator-activated receptors(PPARs)are nuclear hormone receptors that can be activated by xenobiotics and natural fatty acids. To assess the potential physiological activity of PPAR ligands on cardiac muscular cells, the effects of PPARα agonist, WY-14, 643, on both rat hearts and a rat cardiomyocyte cell line(H9c2 cells)were investigated. Male F344 rats were fed a diet containing WY-14, 643 at a concentration of 100 ppm for 26 weeks. Cardiac muscular hypertrophy was revealed by morphometric analysis in which the diameter of the muscular fibers in WY-14, 643-treated rats was larger than those of control rats. Using H9c2 cells in vitro, the protein content per cell was increased in a dose-dependent manner with the treatment of WY-14, 643. The transcription of myosin light chain-2(MLC-2), a parameter of myocardial hypertrophy, was increased in H9c2 cells transfected with the rat MLC-2/luciferase fusion gene by WY-14, 643 as well as other peroxisome proliferators, clofibrate and di(2-eth-ylhexyl)phthalate. In addition, accumulation of myosin light chain protein was confirmed in H9c2 cells treated with W\\<br/>Y-14, 643 at 10 μg/ml for 7 days or more by immunohistochemistry. These results suggest that PPARα ligands have a potential to regulate MLC-2, which is a contractile protein in cardiomyocytes and may play a part of role in the pathogenesis of cardiac hypertrophy.","subitem_description_type":"Abstract"}]},"item_12_relation_54":{"attribute_name":"異版である","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ci.nii.ac.jp/naid/110001807057/","subitem_relation_type_select":"URI"}}]},"item_12_rights_14":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本トキシコロジー学会"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_12_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_12_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00002808","subitem_source_identifier_type":"NCID"}]},"item_12_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03881350","subitem_source_identifier_type":"ISSN"}]},"item_12_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_12_subject_24":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_12_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"1637341 bytes"}]},"item_12_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"学術雑誌論文"}]},"item_12_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal Article"}]},"item_12_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_12_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"01"}]},"item_12_text_79":{"attribute_name":"所属","attribute_value_mlt":[{"subitem_text_value":"Toxicology Laboratory, Mitsubishi Pharma Co.:Graduate School of Humanities and Sciences, Ochanomizu University"},{"subitem_text_value":"2Toxicology Laboratory, Mitsubishi Pharma Co"},{"subitem_text_value":"Toxicology Laboratory, Mitsubishi Pharma Co."},{"subitem_text_value":"Graduate School of Humanities and Sciences, Ochanomizu University"},{"subitem_text_value":"Toxicology Laboratory, Mitsubishi Pharma Co"}]},"item_1622774516477":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"HAMANO, Takako"}],"nameIdentifiers":[{"nameIdentifier":"66231","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KOBAYASHI, Kiyoshi"}],"nameIdentifiers":[{"nameIdentifier":"66232","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SAKAIRI, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"66233","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HAYASHI, Masao"}],"nameIdentifiers":[{"nameIdentifier":"66234","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MUTAI, Mamoru"}],"nameIdentifiers":[{"nameIdentifier":"66235","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-19"}],"displaytype":"detail","filename":"J of toxicological sciences26(5)_hamanohayashi.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"J of toxicological sciences26(5)_hamanohayashi.pdf","url":"https://teapot.lib.ocha.ac.jp/record/4893/files/J of toxicological sciences26(5)_hamanohayashi.pdf"},"version_id":"5d8dfad2-5bf4-4b4f-be36-cfa3e84e8420"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Peroxisome proliferator-activated receptor α agonist","subitem_subject_scheme":"Other"},{"subitem_subject":"WY-14,643 Cardiac","subitem_subject_scheme":"Other"},{"subitem_subject":"hypertrophy Myosin light","subitem_subject_scheme":"Other"},{"subitem_subject":"chain-2","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α(PPARα)AGONIST, WY-14, 643, INCREASED TRANSCRIPTION OF MYOSIN LIGHT CHAIN-2 IN CARDIOMYOCYTES","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α(PPARα)AGONIST, WY-14, 643, INCREASED TRANSCRIPTION OF MYOSIN LIGHT CHAIN-2 IN CARDIOMYOCYTES","subitem_title_language":"en"}]},"item_type_id":"12","owner":"1","path":["221"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-04-14"},"publish_date":"2008-04-14","publish_status":"0","recid":"4893","relation_version_is_last":true,"title":["PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α(PPARα)AGONIST, WY-14, 643, INCREASED TRANSCRIPTION OF MYOSIN LIGHT CHAIN-2 IN CARDIOMYOCYTES"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-12T06:02:22.707549+00:00"}