WEKO3
アイテム
In silico identification and microarray analysis of human mucin-like genes
http://hdl.handle.net/10083/35272
http://hdl.handle.net/10083/35272380f443e-db76-466f-b437-6879f0bf2ae8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00005461417.pdf (1.6 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-10-28 | |||||
| タイトル | ||||||
| タイトル | In silico identification and microarray analysis of human mucin-like genes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
Nishi-Takaoka, Chikako
× Nishi-Takaoka, Chikako× Nishi, Tatsunari× Shimamura, Takahiro× Yamamoto, Shogo× Hippo, Yoshitaka× Aburatani, Hiroyuki |
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| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 70968 | |||||
| 姓名 | ニシ-タカオカ, チカコ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 70969 | |||||
| 姓名 | ニシ, タツナリ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 70970 | |||||
| 姓名 | シマムラ, タカヒロ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 70971 | |||||
| 姓名 | ヤマモト, ショウゴ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 70972 | |||||
| 姓名 | ヒッポ, ヨシタカ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 70973 | |||||
| 姓名 | アブラタニ, ヒロユキ | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Mucins, which are highly O-glycosylated proteins, are involved in a variety of diseases. Most of the known mucins show little sequence conservation. To identify novel candidate mucins that might be helpful for diagnosis and therapy of diseases, bioinformatics approaches other than homology searches are required. We have developed two bioinformatics approaches that focus on either the amino acid compositions or the repeated sequences in regions carrying 0-linked glycans. Both approaches identify candidate mucins efficiently from the human reference sequence database. The former and latter approaches identified three and two novel mucin-like genes, respectively. We used Affymetrix GeneChip oligonucleotide microarrays to analyze the mucins identified from the database and found that three human mucin genes differed significantly in expression between normal tissues/cells and cancer cell lines. A combination of our bioinformatics approaches and the oligonucleotide microarray method will be useful for the efficient identification of candidate human mucins. Further study of the mucins in cancer tissues will facilitate\ the direct evaluation of their potential for cancer diagnosis and therapy. |
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| 書誌情報 |
お茶の水女子大學自然科學報告 巻 58, 号 1, p. 71-89, 発行日 2007-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00298190 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00033958 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 1611541 bytes | ||||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 400 | |||||
| 出版者 | ||||||
| 出版者 | お茶の水女子大学 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 紀要論文 | |||||
| 資源タイプ・ローカル | ||||||
| 紀要論文 | ||||||
| 資源タイプ・NII | ||||||
| Departmental Bulletin Paper | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
| 03 | ||||||
| 所属 | ||||||
| Genaris, Inc.:Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo | ||||||
| 所属 | ||||||
| Genaris, Inc.:Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo | ||||||
| 所属 | ||||||
| Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo | ||||||
| 所属 | ||||||
| Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo | ||||||
| 所属 | ||||||
| Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo | ||||||
| 所属 | ||||||
| Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo | ||||||
