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  1. 紀要
  2. お茶の水女子大學自然科學報告
  3. 53(1)

Biological Functions of a Novel Lipid Mediator, Cyclic Phosphatidic Acid (cPA)

http://hdl.handle.net/10083/2359
http://hdl.handle.net/10083/2359
ed1630e1-d32f-4f45-b39e-7d848b2136c3
名前 / ファイル ライセンス アクション
KJ00004830727.pdf KJ00004830727.pdf (361.1 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2008-04-30
タイトル
タイトル Biological Functions of a Novel Lipid Mediator, Cyclic Phosphatidic Acid (cPA)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Kobayashi, Tetsuyuki

× Kobayashi, Tetsuyuki

WEKO 70734

Kobayashi, Tetsuyuki

Search repository
Murakami-Murofushi, Kimiko

× Murakami-Murofushi, Kimiko

WEKO 70735

Murakami-Murofushi, Kimiko

Search repository
著者(ヨミ)
識別子 70736
識別子Scheme WEKO
姓名 コバヤシ, テツユキ
著者(ヨミ)
識別子 70737
識別子Scheme WEKO
姓名 ムラカミ(ムロフシ), キミコ
内容記述
内容記述タイプ Other
内容記述 Cyclic phosphatidic acid (cPA) possessing phosphate at sn-2 and -3 positions of glycerol is a unique analog of lysophosphatidic acid (LPA). The biosynthesis and functions of cPA as a novel lipid mediator have been studied. The biosynthetic enzyme activity of cPA was detected in sera from rat, bovine and human using lysophosphatidylcholine as a substrate. The reaction is considered to be catalyzed by a phospholipase D -like enzyme. The naturally occurring cPA and some of their analogs showed a variety of biological activities. cPA showed an inhibitory effect on cdc25 phosphatase in vitro, while no effect on activities of cdks. It was also shown that dephosphorylated (active) form of cdk2 decreased when cPA was added into cultures of human fibroblast cells caused a decrease in dephosphorylated (active) form of cdk2. These results suggested that suppression of cell proliferation by cPA is caused by the inhibition of cdc25 phosphatase. LPA induced tumor cell invasion, whereas cPA suppressed the LPA-induced invasion. cPA containing C16:0 was most potent in inhibiting tumor cell invasion (transcellular migration) in an i\
n vitro system as compared with other molecular. These findings support the idea that cPA is formed as a physiological constituent, and functions as one of the bioactive lipids in mammalian cells.
書誌情報 お茶の水女子大學自然科學報告

巻 53, 号 1, p. 45-48, 発行日 2002-06
ISSN
収録物識別子タイプ ISSN
収録物識別子 00298190
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00033958
フォーマット
内容記述タイプ Other
内容記述 application/pdf
形態
361101 bytes
日本十進分類法
主題Scheme NDC
主題 400
出版者
出版者 お茶の水女子大学
資源タイプ
内容記述タイプ Other
内容記述 紀要論文
資源タイプ・ローカル
紀要論文
資源タイプ・NII
Departmental Bulletin Paper
資源タイプ・DCMI
text
資源タイプ・ローカル表示コード
03
所属
Department of Biology, Faculty of Science, Ochanomizu University
所属
Department of Biology, Faculty of Science, Ochanomizu University
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