WEKO3
アイテム
DREF, a Transcriptional Regulatory Factor Related to Cell Proliferation
http://hdl.handle.net/10083/2361
http://hdl.handle.net/10083/23611626f1da-3edd-494b-accf-f371c3efafd2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004830729.pdf (683.8 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-04-30 | |||||
| タイトル | ||||||
| タイトル | DREF, a Transcriptional Regulatory Factor Related to Cell Proliferation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
Maruyama, Midori
× Maruyama, Midori× Inoue, Makiko× Koike, Akiko× Shuto, Tomoko× Ikeda, Akiko× Yoshida, Hideki× Yamaguchi, Masamitsu× Hirose, Fumiko× Matsukage, Akio |
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| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 70753 | |||||
| 姓名 | マルヤマ, ミドリ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 70754 | |||||
| 姓名 | イノウエ, マキコ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 70755 | |||||
| 姓名 | コイケ, アキコ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 70756 | |||||
| 姓名 | シュウトウ, トモコ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 70757 | |||||
| 姓名 | イケダ, アキコ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 70758 | |||||
| 姓名 | ヨシダ, ヒデキ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 70759 | |||||
| 姓名 | ヤマグチ, マサミツ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 70760 | |||||
| 姓名 | ヒロセ, フミコ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 70761 | |||||
| 姓名 | マツカゲ, アキオ | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Coordinate expression of many cell proliferation-related genes is required for the cellular shift from resting state into proliferating state. For a candidate of the regulatory factors involved this process, we found a transcription regulatory factor named DREF (DNA replication-related element-binding factor) in Drosophila and then in mammalian systems. Drosophila DREF consists of a homodimer of the polypeptide of 709 amino acid residues, and shears about 22% identities of amino acid sequences with the human homolog which consists of 694 amino acid residues. Drosophila DREF binds specifically to the DRE sequence (5'-TATCGATA-3') in the promoters of many DNA replication/cell proliferation-related genes to activate their transcription. Ectopic expression of DREF in larval imaginal discs induce abnormal DNA synthesis, apoptosis and failures in differentiation. Both Drosophila and mammalian DREF's interact genetically and physically with regulatory factors related to chromatin structures, suggesting that DREF activates the expression of proliferation-related genes through modification of chromatin structures. By sea\ rching the Drosophila genome, we found about 150 genes which carry DRE sequences in their promoter regions, interestingly many of which are related to reactions required for cell proliferation such as DNA replication, transcription, transcriptional regulation, cell cycle regulation, growth signal transduction, protein metabolism. Thus, DREF is a master key-like factor for cell proliferation. |
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| 書誌情報 |
お茶の水女子大學自然科學報告 巻 53, 号 1, p. 55-62, 発行日 2002-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00298190 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00033958 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 683754 bytes | ||||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 400 | |||||
| 出版者 | ||||||
| 出版者 | お茶の水女子大学 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 紀要論文 | |||||
| 資源タイプ・ローカル | ||||||
| 紀要論文 | ||||||
| 資源タイプ・NII | ||||||
| Departmental Bulletin Paper | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
| 03 | ||||||
| 所属 | ||||||
| Department of Chemical and Biological Sciences, Japan Women's University | ||||||
| 所属 | ||||||
| Department of Chemical and Biological Sciences, Japan Women's University | ||||||
| 所属 | ||||||
| Department of Chemical and Biological Sciences, Japan Women's University | ||||||
| 所属 | ||||||
| Department of Chemical and Biological Sciences, Japan Women's University | ||||||
| 所属 | ||||||
| Department of Chemical and Biological Sciences, Japan Women's University | ||||||
| 所属 | ||||||
| Kyoto Institute of Technology | ||||||
| 所属 | ||||||
| Kyoto Institute of Technology | ||||||
| 所属 | ||||||
| Aichi Cancer Center Research Institute | ||||||
| 所属 | ||||||
| Department of Chemical and Biological Sciences, Japan Women's University | ||||||
