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Fibroblast growth factor-2 (FGF-2) stimulates the growth of hMSCs in vitro, but its mechanisms have not been clarified yet. In this study, we investigated whether cellular senescence was involved in the stimulation of hMSCs growth by FGF-2 and the expression levels of transforming growth factor-\u03b21 and -\u03b22 (TGF-\u03b2s). Because hMSCs were induced cellular senescence due to long-term culture, FGF-2 decreased the percentage of senescent cells and suppressed G1 cell growth arrest through the suppression of p21(Cip1), p53, and p16(INK4a) mRNA expression levels. Furthermore, the levels of TGF-\u03b2s mRNA expression in hMSCs were increased by long-term culture, but FGF-2 suppressed the increase of TGF-\u03b22 mRNA expression due to long-term culture. These results suggest that FGF-2 suppresses the hMSCs cellular senescence dependent on the length of culture through down-regulation of TGF-\u03b22 expression.", "subitem_description_type": "Abstract"}]}, "item_12_publisher_36": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Academic Press"}]}, "item_12_relation_12": {"attribute_name": "PubMed\u756a\u53f7", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "17532297", "subitem_relation_type_select": "PMID"}}]}, "item_12_relation_54": {"attribute_name": "\u7570\u7248\u3067\u3042\u308b", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.bbrc.2007.05.067", "subitem_relation_type_select": "URI"}}]}, "item_12_relation_63": {"attribute_name": "\u53c2\u7167\u3059\u308b", "attribute_value_mlt": [{"subitem_relation_type": "references", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description", "subitem_relation_type_select": "URI"}}]}, "item_12_rights_14": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "Copyright \u00a9 2007 Elsevier Inc. 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