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Examination of The Correlation between DNA-dependent Protein Kinase and Telomerase Activity
http://hdl.handle.net/10083/855
http://hdl.handle.net/10083/855f628d473-05b5-4ee5-bce2-a6efc37039ec
名前 / ファイル | ライセンス | アクション |
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KJ00004470889.pdf (1.2 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-04-23 | |||||
タイトル | ||||||
タイトル | Examination of The Correlation between DNA-dependent Protein Kinase and Telomerase Activity | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Ikeda, Fumi
× Ikeda, Fumi× Matsumoto, Yoshihisa× Suzuki, Norio× Murakami-Murofushi, Kimiko |
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著者(ヨミ) | ||||||
識別子 | 70637 | |||||
識別子Scheme | WEKO | |||||
姓名 | イケダ, フミ | |||||
著者(ヨミ) | ||||||
識別子 | 70638 | |||||
識別子Scheme | WEKO | |||||
姓名 | マツモト, ヨシヒサ | |||||
著者(ヨミ) | ||||||
識別子 | 70639 | |||||
識別子Scheme | WEKO | |||||
姓名 | スズキ, ノリオ | |||||
著者(ヨミ) | ||||||
識別子 | 70640 | |||||
識別子Scheme | WEKO | |||||
姓名 | ムラカミ-ムロフシ, キミコ | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Telomerase is known as a ribonucleoprotein enzyme essential for the repair of replication-induced deletion of chromosome terminal in most eukaryotes. Although the regulatory mechanism of telomerase inactivation and re-activation has not yet been clarified, there is a possibility that telomerase activity is regulated by phosphorylation and dephosphorylation. DNA-dependent protein kinase (DNA-PK) is considered to be a critical enzyme in DNA double-strand break repair and possibility of involvement of this enzyme in the regulation of telomerase is expected. To examin correlation between telomerase and DNA-PK, we purified DNA-PK from human leukaemic MOLT-4 cells by successive column chromatography. Through the conventional process of purification, DNA-PK activity was accompanied by telomerase activity. We used modified purification protcol in this study, and tinaly, succeeded in purification of DNA-PK separately from telomerase activity. This DNA-PK didn't show any effect on the telomerase activity, and these results indicate that the telomerase may not be regulated via phosphorylation with DNA-PK. | |||||
書誌情報 |
お茶の水女子大學自然科學報告 巻 49, 号 1, p. 7-12, 発行日 1998-08-30 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00298190 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00033958 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
形態 | ||||||
1151019 bytes | ||||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 400 | |||||
出版者 | ||||||
出版者 | お茶の水女子大学 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | 紀要論文 | |||||
資源タイプ・ローカル | ||||||
紀要論文 | ||||||
資源タイプ・NII | ||||||
Departmental Bulletin Paper | ||||||
資源タイプ・DCMI | ||||||
text | ||||||
資源タイプ・ローカル表示コード | ||||||
03 | ||||||
所属 | ||||||
Department of Biology, Faculty of Sience, Ochanomizu University | ||||||
所属 | ||||||
Department of Radiation Oncology, Faculty of Medicine, University of Tokyo | ||||||
所属 | ||||||
Department of Radiation Oncology, Faculty of Medicine, University of Tokyo | ||||||
所属 | ||||||
Department of Biology, Faculty of Sience, Ochanomizu University |