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アイテム
Examination of The Correlation between DNA-dependent Protein Kinase and Telomerase Activity
http://hdl.handle.net/10083/855
http://hdl.handle.net/10083/855f628d473-05b5-4ee5-bce2-a6efc37039ec
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004470889.pdf (1.2 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-04-23 | |||||
| タイトル | ||||||
| タイトル | Examination of The Correlation between DNA-dependent Protein Kinase and Telomerase Activity | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
Ikeda, Fumi
× Ikeda, Fumi× Matsumoto, Yoshihisa× Suzuki, Norio× Murakami-Murofushi, Kimiko |
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| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 70637 | |||||
| 姓名 | イケダ, フミ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 70638 | |||||
| 姓名 | マツモト, ヨシヒサ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 70639 | |||||
| 姓名 | スズキ, ノリオ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 70640 | |||||
| 姓名 | ムラカミ-ムロフシ, キミコ | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Telomerase is known as a ribonucleoprotein enzyme essential for the repair of replication-induced deletion of chromosome terminal in most eukaryotes. Although the regulatory mechanism of telomerase inactivation and re-activation has not yet been clarified, there is a possibility that telomerase activity is regulated by phosphorylation and dephosphorylation. DNA-dependent protein kinase (DNA-PK) is considered to be a critical enzyme in DNA double-strand break repair and possibility of involvement of this enzyme in the regulation of telomerase is expected. To examin correlation between telomerase and DNA-PK, we purified DNA-PK from human leukaemic MOLT-4 cells by successive column chromatography. Through the conventional process of purification, DNA-PK activity was accompanied by telomerase activity. We used modified purification protcol in this study, and tinaly, succeeded in purification of DNA-PK separately from telomerase activity. This DNA-PK didn't show any effect on the telomerase activity, and these results indicate that the telomerase may not be regulated via phosphorylation with DNA-PK. | |||||
| 書誌情報 |
お茶の水女子大學自然科學報告 巻 49, 号 1, p. 7-12, 発行日 1998-08-30 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00298190 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00033958 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 1151019 bytes | ||||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 400 | |||||
| 出版者 | ||||||
| 出版者 | お茶の水女子大学 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 紀要論文 | |||||
| 資源タイプ・ローカル | ||||||
| 紀要論文 | ||||||
| 資源タイプ・NII | ||||||
| Departmental Bulletin Paper | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
| 03 | ||||||
| 所属 | ||||||
| Department of Biology, Faculty of Sience, Ochanomizu University | ||||||
| 所属 | ||||||
| Department of Radiation Oncology, Faculty of Medicine, University of Tokyo | ||||||
| 所属 | ||||||
| Department of Radiation Oncology, Faculty of Medicine, University of Tokyo | ||||||
| 所属 | ||||||
| Department of Biology, Faculty of Sience, Ochanomizu University | ||||||
