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KUPFFER CELL-MEDIATED CYTOTOXICITY INDUCED BY LIPOPOLYSACCHARIDE0111:B4 IS GREATER IN DOGS THAN IN RATS AND MONKEYS
http://hdl.handle.net/10083/1856
http://hdl.handle.net/10083/1856c2dbf52a-5371-4114-b256-766b3d7cbb19
名前 / ファイル | ライセンス | アクション |
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J of toxicological sciences27(1)_hayashi.pdf (904.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-04-14 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | KUPFFER CELL-MEDIATED CYTOTOXICITY INDUCED BY LIPOPOLYSACCHARIDE0111:B4 IS GREATER IN DOGS THAN IN RATS AND MONKEYS | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Kupffer cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lipopolysaccharide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cytokine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cytotoxicity | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
HAMANO, Takako
× HAMANO, Takako× TONG, Vincent× MUTAI, Mamoru× HAYASHI, Masao× TANAKA, Eiji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To clarify the mechanism of sensitivity to an endotoxin lipopolysaccharide LPS0111 :B4, which causes severe liver injury in a variety of animals, we have developed an in vitro assay to measure Kupffer cell-mediated cytotoxicity in the human liver cell line, WRL68. This assay could detect the decrease in Kupffer cell activity induced by gadolinium chloride (GdCl_3), which is an inhibitor in Kupffer cells. Among Kupffer cells derived from dogs, rats, and monkeys, LPS-activated canine Kupffer cells exhibited remarkably high cytotoxicity against WRL68 cells. This species difference is correlated with a species difference in the lethality of LPS0111 :B4. Additionally, the conditioned medium of LPS-activated canine Kupffer cells was also cytotoxic to WRL68 cells. To identify the mediators of this cytotoxicity, we measured the accelerated release of interleukin- 1β, and interleukin-6 from Kupffer cells on stimulation with LPS0111 :B4. From the correlation of the response to LPS0111 :B4, interleukin-1β and interleukin-6 are considered to be responsible for the canine Kupffer cell-mediated cytotoxicity of LPS0111 :B4. | |||||
書誌情報 |
Journal of toxicological sciences 巻 27, 号 1, p. 1-9, 発行日 2002-02-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03881350 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00002808 | |||||
権利 | ||||||
権利情報 | 日本トキシコロジー学会 | |||||
権利 | ||||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
形態 | ||||||
904437 bytes | ||||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
著者版フラグ | ||||||
値 | publisher | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 医学 | |||||
出版者 | ||||||
出版者 | 日本トキシコロジー学会 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | 学術雑誌論文 | |||||
資源タイプ・ローカル | ||||||
学術雑誌論文 | ||||||
資源タイプ・NII | ||||||
Journal Article | ||||||
資源タイプ・DCMI | ||||||
text | ||||||
資源タイプ・ローカル表示コード | ||||||
01 | ||||||
異版である | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://ci.nii.ac.jp/naid/110001807064/ | |||||
所属 | ||||||
Toxicology Laboratory, Mitsubishi Pharma Corporation:Graduate School of Humanities and Sciences, Ochanomizu University | ||||||
所属 | ||||||
Toxicology Laboratory, Mitsubishi Pharma Corporation | ||||||
所属 | ||||||
Toxicology Laboratory, Mitsubishi Pharma Corporation | ||||||
所属 | ||||||
Graduate School of Humanities and Sciences, Ochanomizu University | ||||||
所属 | ||||||
Toxicology Laboratory, Mitsubishi Pharma Corporation |