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This assay could detect the decrease in Kupffer cell activity induced by gadolinium chloride (GdCl_3), which is an inhibitor in Kupffer cells. Among Kupffer cells derived from dogs, rats, and monkeys, LPS-activated canine Kupffer cells exhibited remarkably high cytotoxicity against WRL68 cells. This species difference is correlated with a species difference in the lethality of LPS0111 :B4. Additionally, the conditioned medium of LPS-activated canine Kupffer cells was also cytotoxic to WRL68 cells. To identify the mediators of this cytotoxicity, we measured the accelerated release of interleukin- 1β, and interleukin-6 from Kupffer cells on stimulation with LPS0111 :B4. From the correlation of the response to LPS0111 :B4, interleukin-1β and interleukin-6 are considered to be responsible for the canine Kupffer cell-mediated cytotoxicity of LPS0111 :B4.", "subitem_description_type": "Abstract"}]}, "item_12_publisher_36": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本トキシコロジー学会"}]}, "item_12_relation_54": {"attribute_name": "異版である", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://ci.nii.ac.jp/naid/110001807064/", "subitem_relation_type_select": "URI"}}]}, "item_12_rights_14": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "日本トキシコロジー学会"}, {"subitem_rights": "本文データは学協会の許諾に基づきCiNiiから複製したものである"}]}, "item_12_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_12_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": 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