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KUPFFER CELL-MEDIATED CYTOTOXICITY INDUCED BY LIPOPOLYSACCHARIDE0111:B4 IS GREATER IN DOGS THAN IN RATS AND MONKEYS
http://hdl.handle.net/10083/1856
http://hdl.handle.net/10083/1856c2dbf52a-5371-4114-b256-766b3d7cbb19
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
J of toxicological sciences27(1)_hayashi.pdf (904.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-04-14 | |||||
| タイトル | ||||||
| タイトル | KUPFFER CELL-MEDIATED CYTOTOXICITY INDUCED BY LIPOPOLYSACCHARIDE0111:B4 IS GREATER IN DOGS THAN IN RATS AND MONKEYS | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Kupffer cells | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Lipopolysaccharide | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cytokine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cytotoxicity | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
HAMANO, Takako
× HAMANO, Takako× TONG, Vincent× MUTAI, Mamoru× HAYASHI, Masao× TANAKA, Eiji |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To clarify the mechanism of sensitivity to an endotoxin lipopolysaccharide LPS0111 :B4, which causes severe liver injury in a variety of animals, we have developed an in vitro assay to measure Kupffer cell-mediated cytotoxicity in the human liver cell line, WRL68. This assay could detect the decrease in Kupffer cell activity induced by gadolinium chloride (GdCl_3), which is an inhibitor in Kupffer cells. Among Kupffer cells derived from dogs, rats, and monkeys, LPS-activated canine Kupffer cells exhibited remarkably high cytotoxicity against WRL68 cells. This species difference is correlated with a species difference in the lethality of LPS0111 :B4. Additionally, the conditioned medium of LPS-activated canine Kupffer cells was also cytotoxic to WRL68 cells. To identify the mediators of this cytotoxicity, we measured the accelerated release of interleukin- 1β, and interleukin-6 from Kupffer cells on stimulation with LPS0111 :B4. From the correlation of the response to LPS0111 :B4, interleukin-1β and interleukin-6 are considered to be responsible for the canine Kupffer cell-mediated cytotoxicity of LPS0111 :B4. | |||||
| 書誌情報 |
Journal of toxicological sciences 巻 27, 号 1, p. 1-9, 発行日 2002-02-25 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03881350 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00002808 | |||||
| 権利 | ||||||
| 権利情報 | 日本トキシコロジー学会 | |||||
| 権利 | ||||||
| 権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 904437 bytes | ||||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| NIIサブジェクト | ||||||
| 主題Scheme | Other | |||||
| 主題 | 医学 | |||||
| 出版者 | ||||||
| 出版者 | 日本トキシコロジー学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学術雑誌論文 | |||||
| 資源タイプ・ローカル | ||||||
| 学術雑誌論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
| 01 | ||||||
| 異版である | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://ci.nii.ac.jp/naid/110001807064/ | |||||
| 所属 | ||||||
| Toxicology Laboratory, Mitsubishi Pharma Corporation:Graduate School of Humanities and Sciences, Ochanomizu University | ||||||
| 所属 | ||||||
| Toxicology Laboratory, Mitsubishi Pharma Corporation | ||||||
| 所属 | ||||||
| Toxicology Laboratory, Mitsubishi Pharma Corporation | ||||||
| 所属 | ||||||
| Graduate School of Humanities and Sciences, Ochanomizu University | ||||||
| 所属 | ||||||
| Toxicology Laboratory, Mitsubishi Pharma Corporation | ||||||
