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PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α(PPARα)AGONIST, WY-14, 643, INCREASED TRANSCRIPTION OF MYOSIN LIGHT CHAIN-2 IN CARDIOMYOCYTES
http://hdl.handle.net/10083/1858
http://hdl.handle.net/10083/1858281c45e2-7672-4f30-9872-8b6d5d4d3b2d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
J of toxicological sciences26(5)_hamanohayashi.pdf (1.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-04-14 | |||||
| タイトル | ||||||
| タイトル | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α(PPARα)AGONIST, WY-14, 643, INCREASED TRANSCRIPTION OF MYOSIN LIGHT CHAIN-2 IN CARDIOMYOCYTES | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Peroxisome proliferator-activated receptor α agonist | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | WY-14,643 Cardiac | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hypertrophy Myosin light | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | chain-2 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
HAMANO, Takako
× HAMANO, Takako× KOBAYASHI, Kiyoshi× SAKAIRI, Tetsuya× HAYASHI, Masao× MUTAI, Mamoru |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Peroxisome proliferator-activated receptors(PPARs)are nuclear hormone receptors that can be activated by xenobiotics and natural fatty acids. To assess the potential physiological activity of PPAR ligands on cardiac muscular cells, the effects of PPARα agonist, WY-14, 643, on both rat hearts and a rat cardiomyocyte cell line(H9c2 cells)were investigated. Male F344 rats were fed a diet containing WY-14, 643 at a concentration of 100 ppm for 26 weeks. Cardiac muscular hypertrophy was revealed by morphometric analysis in which the diameter of the muscular fibers in WY-14, 643-treated rats was larger than those of control rats. Using H9c2 cells in vitro, the protein content per cell was increased in a dose-dependent manner with the treatment of WY-14, 643. The transcription of myosin light chain-2(MLC-2), a parameter of myocardial hypertrophy, was increased in H9c2 cells transfected with the rat MLC-2/luciferase fusion gene by WY-14, 643 as well as other peroxisome proliferators, clofibrate and di(2-eth-ylhexyl)phthalate. In addition, accumulation of myosin light chain protein was confirmed in H9c2 cells treated with W\<br/>Y-14, 643 at 10 μg/ml for 7 days or more by immunohistochemistry. These results suggest that PPARα ligands have a potential to regulate MLC-2, which is a contractile protein in cardiomyocytes and may play a part of role in the pathogenesis of cardiac hypertrophy. | |||||
| 書誌情報 |
Journal of toxicological sciences 巻 26, 号 5, p. 275-284, 発行日 2001-12-21 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03881350 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00002808 | |||||
| 権利 | ||||||
| 権利情報 | 日本トキシコロジー学会 | |||||
| 権利 | ||||||
| 権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 1637341 bytes | ||||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| NIIサブジェクト | ||||||
| 主題Scheme | Other | |||||
| 主題 | 医学 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学術雑誌論文 | |||||
| 資源タイプ・ローカル | ||||||
| 学術雑誌論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
| 01 | ||||||
| 異版である | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://ci.nii.ac.jp/naid/110001807057/ | |||||
| 所属 | ||||||
| Toxicology Laboratory, Mitsubishi Pharma Co.:Graduate School of Humanities and Sciences, Ochanomizu University | ||||||
| 所属 | ||||||
| 2Toxicology Laboratory, Mitsubishi Pharma Co | ||||||
| 所属 | ||||||
| Toxicology Laboratory, Mitsubishi Pharma Co. | ||||||
| 所属 | ||||||
| Graduate School of Humanities and Sciences, Ochanomizu University | ||||||
| 所属 | ||||||
| Toxicology Laboratory, Mitsubishi Pharma Co | ||||||
