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  1. その他のコレクション
  2. NDC
  3. 4 自然科学

Pseudoproteoglycan (pseudoPG) probes that simulate PG macromolecular structure for screening and isolation of PG-binding proteins

http://hdl.handle.net/10083/35135
http://hdl.handle.net/10083/35135
b2395de2-9a0e-492a-befc-0b55f850667a
名前 / ファイル ライセンス アクション
Glycoconjugate Glycoconjugate Journal 2009 Feb 21. [Epub ahead of print].doc.pdf (782.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-01-26
タイトル
言語 en
タイトル Pseudoproteoglycan (pseudoPG) probes that simulate PG macromolecular structure for screening and isolation of PG-binding proteins
言語
言語 eng
キーワード
主題Scheme Other
主題 Glycosaminoglycan
キーワード
主題Scheme Other
主題 Heparin
キーワード
主題Scheme Other
主題 binding proteins
キーワード
主題Scheme Other
主題 Cyclophilin A
キーワード
主題Scheme Other
主題 HSP90
キーワード
主題Scheme Other
主題 Amphoterin
キーワード
主題Scheme Other
主題 Detection and separation
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 Nakagawa, Keiko

× Nakagawa, Keiko

WEKO 88918

Nakagawa, Keiko

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Nakamura, Kosuke

× Nakamura, Kosuke

WEKO 88919

Nakamura, Kosuke

Search repository
Haishima, Yuji

× Haishima, Yuji

WEKO 88920

Haishima, Yuji

Search repository
Yamagami, Makiko

× Yamagami, Makiko

WEKO 88921

Yamagami, Makiko

Search repository
Saito, Kana

× Saito, Kana

WEKO 88922

Saito, Kana

Search repository
Sakagami, Hiromi

× Sakagami, Hiromi

WEKO 88923

Sakagami, Hiromi

Search repository
Ogawa, Haruko

× Ogawa, Haruko

WEKO 88924

Ogawa, Haruko

Search repository
抄録
内容記述タイプ Abstract
内容記述 A proteoglycan (PG) monomer is a macromolecule consisting of one or more glycosaminoglycan (GAG) chains attached to a core protein. PGs have signaling roles and modulatory functions in the extracellular matrix and at the cell surface. To elucidate the functions of higher-order PG structures, pseudoPGs that imitate the PG structure were prepared to develop probes and affinity adsorbents. Poly-L-lysine (PLL) or polyacrylamide (PAA) was coupled with various GAGs, then biotinylated, and the remaining amino groups were blocked to obtain the pseudoPG probes, biotinyl PLL (BPL)- or PAA (BPA)-GAGs. Lactoferrin exhibited 30-times higher affinity toward BPL-heparin than the conventional single-strand probe, biotin-hydrazide-heparin.Heparin-PLL was immobilized on a formyl-Sepharose and compared with the Hep-Sepharose in which heparin was directly immobilized to amino-Sepharose. Screening for ligands in normal rat brain revealed several proteins that specifically bound to either of the two adsorbents, indicating that the heparin-binding proteins exhibit specific recognition depending on the higher-order structure of the PG.
内容記述
内容記述タイプ Other
内容記述 online first / <br/>Received: 28 July 2008 / Revised: 30 September 2008 / Accepted: 8 December 2008 / Published online: 21 February 2009
内容記述
内容記述タイプ Other
内容記述 The original publication is available at www.springerlink.com
書誌情報 Glycoconjugate Journal

発行日 2009-02-21
ISSN
収録物識別子タイプ ISSN
収録物識別子 02820080
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11981860
権利
権利情報 Springer Science + Business Media, LLC 2009
フォーマット
内容記述タイプ Other
内容記述 application/pdf
フォーマット
内容記述タイプ Other
内容記述 text/plain
フォーマット
内容記述タイプ Other
内容記述 application/pdf
形態
782111 bytes
形態
41649 bytes
形態
27311 bytes
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
著者版フラグ
値 author
日本十進分類法
主題Scheme NDC
主題 464
NIIサブジェクト
主題Scheme Other
主題 生物学
出版者
出版者 Springer Netherlands
資源タイプ
内容記述タイプ Other
内容記述 学術雑誌論文
資源タイプ・ローカル
学術雑誌論文
資源タイプ・NII
Journal Article
資源タイプ・DCMI
text
資源タイプ・ローカル表示コード
01
異版である
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 https://doi.org/10.1007/s10719-008-9220-y
参照する
関連タイプ references
識別子タイプ URI
関連識別子 http://www.springerlink.com/content/880502ul280187v5/
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